A review of tazarotene in the treatment of photodamaged skin
Authors Ogden S, Samuel M, Griffiths CEM
Published 7 March 2008 Volume 2008:3(1) Pages 71—76
Stephanie Ogden1, Miny Samuel2, Christopher EM Griffiths1
1Dermatology Centre, University of Manchester, Hope Hospital, Salford Manchester, M6 8HD, UK; 2RTI-Health Solutions, Williams House, Manchester Science Park, Lloyd Street North, Manchester M15 6SE, UK
Abstract: Chronic sun exposure leads to photodamage, which is characterized clinically by fine and coarse wrinkles, dyspigmentation, telangiectasia, laxity, roughness and a sallow appearance. Many treatments claim to reduce the signs of photodamage, however evidence from randomized controlled trials (RCT) to support these claims is limited. The use of topical retinoids, particularly tretinoin, isotretinoin and tazarotene, has been shown to significantly reduce signs of photodamage both clinically and histologically. Over recent years a number of RCTs, have affirmed that topical tazarotene is an effective and safe treatment for photodamaged skin.
Keywords: photodamage, photoaging, tazarotene, retinoids
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF]