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A review of pulmonary function in Parkinson’s disease

Authors O'Callaghan A, Walker R

Received 4 September 2017

Accepted for publication 29 November 2017

Published 17 April 2018 Volume 2018:8 Pages 13—23

DOI https://doi.org/10.2147/JPRLS.S114309

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Peter Hedera


Ailish O’Callaghan,1 Richard Walker2,3

1Department of Medicine, North Cumbria University Hospitals NHS Trust, Cumbria, 2Department of Medicine, Northumbria Health Care NHS Foundation Trust, Northumbria, 3Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK

Abstract: Idiopathic Parkinson’s disease (PD) is a progressive neurodegenerative disorder, secondary to dopaminergic depletion, which primarily affects motor control via the basal ganglia. It is a multi-system disease affecting dopaminergic neurons throughout the body. The Parkinsonian syndromes are associated with excess morbidity and mortality from respiratory causes. Pulmonary function studies have yielded conflicting results in PD. Understanding the pattern of any respiratory dysfunction in PD, and interventions that could modify these, is of importance in dyspnea, hypoxia, hypercapnia, pneumonia, speech, swallowing, sleep disordered breathing, daytime somnolence, acute respiratory failure, extubation difficulties, increased respiratory infections and reduced exercise tolerance and functional capacity. The aims of this review are to summarize the patterns of pulmonary dysfunction described in previous research in PD, describe the possible implications of pulmonary dysfunction on symptoms in PD, highlight considerations for physicians managing patients and suggest areas for future research.

Keywords: Parkinson’s disease, pulmonary function, lung function, respiratory

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