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A Review of Neuromodulation in the Treatment of Cardiovascular Disease

Authors Yang A, Chakravarthy KV, Pope JE, Deer TR

Received 26 October 2019

Accepted for publication 3 December 2019

Published 18 February 2020 Volume 2020:11 Pages 7—18

DOI https://doi.org/10.2147/RRCC.S210146

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Richard Kones


Video abstract presented by Timothy R Deer.

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Ajax Yang,1 Krishnan V Chakravarthy,2 Jason E Pope,3 Timothy R Deer4

1Department of Anesthesiology, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA; 2Department of Anesthesiology and Pain Medicine, University of California San Diego Health Sciences, La Jolla, CA; VA San Diego Healthcare System, San Diego, CA, USA; 3Evolve Restorative Center, Santa Rosa, CA, USA; 4Center for Pain Relief, Charleston, WV, USA

Correspondence: Timothy R Deer
Center for Pain Relief, 400 Court Street, Suite 100, Charleston, WV 25301, USA
Tel +1304 347 6120
Email tdeermd@centerforpainrelief.com

Introduction: The algorithmic use of neurostimulation to treat chronic pain is routine. However, it is underutilized in managing pain and other symptoms relating to cardiovascular dysfunctions. The goal of this article is to focus on the clinical results from using spinal cord stimulation (SCS) in the realm of cardiovascular medicine.
Material and Methods: The current literature was reviewed, summarized and tabulated. This manuscript contains results from systematic reviews, randomized clinical trials and observational study search results on PubMed spanning the last 30 years. The official positioning statement from the International Neuromodulation Society Neuromodulation Appropriateness Consensus Committee (NACC) was also highlighted.
Results: Evidence supports that SCS is asafe, reversible, minimally-invasive and efficacious modality to mitigate chronic symptoms of refractory angina pectoris and critical limb ischemia.
Discussion: Spinal cord stimulation is effective in providing relief, improve quality of life and functional mobility in patients living with ischemic pain of systemic arterial occlusive disease.
Conclusion: Spinal cord stimulation should be considered early in the treatment algorithm among individuals with inoperable ischemic pain.

Keywords: angina pectoris, critical limb ischemia, ischemic pain, congestive heart failure, Reynaud’s syndrome, spinal cord stimulation

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