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A rare case of lung carcinoma acquires multidrug-resistant Klebsiella pneumoniae pneumonia radiologically mimicking metastasis caused by nivolumab therapy-associated neutropenia

Authors Liu C, Ding L, Zhu Y, Chen C

Received 23 June 2017

Accepted for publication 11 August 2017

Published 12 October 2017 Volume 2017:13 Pages 1375—1377

DOI https://doi.org/10.2147/TCRM.S144681

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 3

Editor who approved publication: Professor Deyun Wang

Chao Liu,* Ling Ding,* Ye-han Zhu, Cheng Chen

Respiratory Department, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China

*These authors contributed equally to this work

Abstract: Nosocomial infections by Klebsiella pneumoniae, especially those due to multidrug-resistant strains, are being increasingly detected. In this report, we present the case of a 63-year-old man with lung squamous carcinoma who received nivolumab therapy due to failure of first-line chemotherapy. This report also demonstrates an association of nivolumab therapy and neutropenia, and supports the use of a combination of tigecycline and meropenem in managing hospitalization-acquired pneumonia caused by multidrug-resistant K. pneumoniae. It also implicates that a further evaluation is required in lung cancer patients with a suspected metastatic or recurrent carcinoma, and an antibiotic therapy is valuable in ruling out a potential lung infection since a risk of hospitalization-acquired pneumonia may exist.

Keywords: hospitalization-acquired pneumonia, nivolumab, neutropenia, lung carcinoma, multidrug-resistant Klebsiella pneumoniae
 

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