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A primary retroperitoneal anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor thrombosis

Authors Li J, Tian X, Wang M, Liu W, Guo X, Wang K, Nong L, Wang W, Yang Y

Received 9 August 2018

Accepted for publication 9 November 2018

Published 12 December 2018 Volume 2018:11 Pages 9007—9011

DOI https://doi.org/10.2147/OTT.S183298

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 4

Editor who approved publication: Dr Arseniy Yuzhalin


Jisong Li,1 Xiaodong Tian,1 Mangju Wang,2 Wei Liu,2 Xiaochao Guo,3 Ke Wang,3 Lin Nong,4 Wei Wang,4 Yinmo Yang1

1Department of General Surgery, Peking University First Hospital, Beijing, China; 2Department of Hematology, Peking University First Hospital, Beijing, China; 3Department of Radiology, Peking University First Hospital, Beijing, China; 4Department of Pathology, Peking University First Hospital, Beijing, China

Abstract: Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a T cell subtype of non-Hodgkin’s lymphoma (NHL). Typically, lymphoma rarely infiltrates vascular structure. In this article, we present a case of retroperitoneal ALK-positive ALCL with splenic venous tumor thrombosis. A 62-year-old patient presented to our institute with the symptoms of epigastric pain, abdominal distension, and reduced bowel movement. Physical examination indicated no enlarged peripheral lymph nodes or abdominal mass. Laboratory workup revealed granulocytosis, abnormal coagulation function, and normal level of lactic dehydrogenase (LDH). Contrast-enhanced computed tomography (CT) showed a retroperitoneal mass with involvement of pancreas and duodenum and formation of splenic venous tumor thrombus. Ultrasonography-guided retroperitoneal lesion biopsy confirmed the diagnosis of ALK-positive ALCL. The patient was able to tolerate oral intake after two cycles of chemotherapy and showed no sign of lymphoma by positron emission tomography (PET)-CT after the fourth cycle of chemotherapy. In spite of its rarity, lymphoma should be taken into account as a differential diagnosis of other malignancies with tumor thrombosis.

Keywords: anaplastic lymphoma kinase, anaplastic large cell lymphoma, primary retroperitoneal lymphoma, tumor thrombosis

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