A predictive tool for foreign body fibrotic reactions using a two-dimensional computational model
Jianzhong Su1, Michail Todorov1,3, Humberto Perez Gonzales1, Larrissa Perkins1, Hristo Kojouharov1, Hong Weng2, Liping Tang2
1Department of Mathematics, 2Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA; 3Faculty of Applied Mathematics and Informatics, Technical University of Sofia, Sofia, Bulgaria
Abstract: It is well established that implanted medical devices often trigger immunological and inflammatory reactions. Such foreign body-mediated tissue responses may result in fibrotic tissue formation surrounding the implants. Despite intensive research in the area of wound healing, few methods are currently available to systematically predict the quantitative behavior of this complex system of multiple cells, proteins, and enzymes. This study introduces a kinetics-based predictive tool in order to analyze outcomes of reactions of various cells/proteins and biochemical processes and to understand transient behavior during the entire implant healing period of up to several months. A computational model in two spatial dimensions is constructed to investigate the time dynamics as well as spatial variation of fibrotic reaction kinetics. Our results support that this model can be used to predict many features in a systematic way and also to forecast the outcomes of complex tissue responses to biomaterial implants.
Keywords: mathematical model, inflammatory responses, foreign body reactions, fibrosis, predictive tool
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF]