Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 6

A pilot study of the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with mucus hypersecretion

Authors Chakravorty I, Chahal, Austin

Published 14 December 2011 Volume 2011:6 Pages 693—699

DOI https://doi.org/10.2147/COPD.S22896

Review by Single-blind

Peer reviewer comments 2

Indranil Chakravorty1, Kamaljit Chahal2, Gillian Austin2
1St George's Hospital, London, 2East and North Hertfordshire NHS Trust, Lister Hospital and Primary Care Trust, Stevenage, Hertfordshire, UK

Introduction: Chronic obstructive pulmonary disease (COPD) patients with mucus hypersecretion tend to demonstrate increased frequency of infective exacerbations and a steeper slope of decline in lung function. Enhanced mucociliary clearance with high-frequency chest wall oscillation (HFCWO) devices previously used in cystic fibrosis and bronchiectasis patients may offer the opportunity for community-based, self-managed therapy to improve quality of life and lung function.
Study design and methods: A randomized controlled crossover pilot study of HFCWO compared with conventional treatment was conducted in 22 patients with moderate to severe COPD and mucus hypersecretion. Patients spent 4 weeks using an HFCWO (SmartVest®) device and 4 weeks in a conventional phase with a 2-week washout. Eleven patients started with HFCWO and changed to conventional treatment, whereas the other eleven patients started conventional treatment and crossed over to HFCWO.
Results: The patients were elderly with a mean age of 71 (standard deviation [SD] 10) years and were at the upper end of the normal range of body mass index (25 [SD 4.2] kg/m2). The majority of patients had moderate to severe COPD with a mean percentage predicted forced expiratory volume in 1 second of 41 (SD 15.6) and percentage predicted forced vital capacity of 73 (SD 17.7). Baseline sputum production was negatively correlated to lung function and positively to St George's Respiratory Questionnaire. Symptom scores and St George's Respiratory Questionnaire symptom dimension improved significantly (-8, P < 0.05). Sputum production showed a declining trend in the HFCWO phase, although not reaching statistical significance. The HFCWO device was well tolerated with good reported compliance.
Conclusion: This pilot study demonstrated that patients with advanced COPD and mucus hypersecretion at increased risk of declining lung function tolerated the HFCWO treatment well, leading to improvement in quality of life and reduced symptoms.

Keywords: sputum volume, bronchiectasis, symptom scopes

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Analysis of autonomic modulation after an acute session of resistance exercise at different intensities in chronic obstructive pulmonary disease patients

Nicolino J, Ramos D, Leite MR, Rodrigues FM, Silva BS, Tacao GY, Toledo AC, Vanderlei LC, Ramos EM

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:223-229

Published Date: 29 January 2015

Chronic obstructive pulmonary disease exacerbation frequency and severity

Stafyla E, Kerenidi T, Gourgoulianis KI

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:533-535

Published Date: 6 November 2013

Quantitative assessment of walking time and postural change in patients with COPD using a new triaxial accelerometer system

Kawagoshi A, Kiyokawa N, Sugawara K, Takahashi H, Sakata S, Miura S, Sawamura S, Satake M, Shioya T

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:397-404

Published Date: 2 September 2013

Exacerbation frequency and course of COPD

Halpin DMG, Decramer M, Celli B, Kesten S, Liu D, Tashkin DP

International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:653-661

Published Date: 21 September 2012