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A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity

Authors Sugimoto K, AKIYAMA T, Shimizu N, Matsumura N, Hayashi T, Nishioka T, Uemura H

Received 21 February 2015

Accepted for publication 18 March 2015

Published 8 May 2015 Volume 2015:7 Pages 81—83

DOI https://doi.org/10.2147/RRU.S83309

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Jan Colli


Koichi Sugimoto,1 Takahiro Akiyama,2 Nobutaka Shimizu,3 Naoki Matsumura,1 Taiji Hayashi,1 Tsukasa Nishioka,1 Hirotsugu Uemura3

1Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Osaka, Japan; 2Department of Urology, Sakai-Onshinkai Hospital, Sakai, Osaka, Japan; 3Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan

Aim: To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity.
Methods: We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were prescribed acotiamide hydrochloride hydrate at a dose of 100 mg three times daily for 2 weeks.
Results: Compared with the post-void residual urinary volume value at baseline (161.4±90.0 mL) a statistically significant reduction was observed at the end of treatment (116.3±63.1 mL) (P=0.006). The drug was generally well tolerated by the majority of patients.
Conclusion: Maybe, acotiamide hydrochloride hydrate showed clinical efficacy in patients with underactive bladders and may, therefore, be used alternatively in patients who do not respond sufficiently to distigmine bromide.

Keywords: acotiamide hydrochloride hydrate, distigmine bromide, underactive bladder, detrusor underactive

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