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A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD

Authors Cantor J, Ma S, Turino G

Received 19 May 2017

Accepted for publication 24 July 2017

Published 18 September 2017 Volume 2017:12 Pages 2747—2752

DOI https://doi.org/10.2147/COPD.S142156

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 4

Editor who approved publication: Dr Richard Russell

Jerome Cantor,1 Shuren Ma,2 Gerard Turino2

1Department of Pharmaceutical Sciences, St John’s University, 2Department of Medicine, St Luke’s Mount Sinai Hospital Center, New York, NY, USA

Abstract: A novel therapy for COPD involving the use of aerosolized hyaluronan (HA) was tested on a small cohort of COPD patients to determine both its safety and efficacy in reducing levels of desmosine and isodesmosine (DID), biomarkers for elastin degradation. In a 2-week, randomized, double-blind trial, 8 patients receiving 150 kDa HA (mean molecular weight) and 3 others given placebo did not show significant adverse effects with regard to spirometry, electrocardiograms, and hematological indices. Furthermore, measurements of DID in plasma from HA-treated patients indicated a progressive decrease over a 3-week period following initiation of treatment (r=−0.98; p=0.02), whereas patients receiving placebo showed no reduction in DID (r=−0.70; p=0.30). Measurements of sputum in the HA-treated group also revealed a progressive decrease in DID (r=−0.97; p=0.03), but this finding was limited by the absence of similar measurements in the placebo group. Nevertheless, the results of this small, pilot study support a longer-term trial of HA in a larger population of COPD patients.

Keywords: hyaluronan, COPD, desmosine, elastin

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