Back to Browse Journals » Virus Adaptation and Treatment » Volume 3

A paradigm linking herpesvirus immediate-early gene expression apoptosis and myalgic encephalomyelitis chronic fatigue syndrome

Authors A Martin Lerner, Safedin Beqaj

Published 21 February 2011 Volume 2011:3 Pages 19—24

DOI https://doi.org/10.2147/VAAT.S15105

Review by Single-blind

Peer reviewer comments 2

A Martin Lerner1, Safedin Beqaj2
1Department of Medicine, William Beaumont Hospital, Royal Oak, MI, USA; 2DCL Medical Laboratories, Indianapolis, IN, USA

Abstract: There is no accepted science to relate herpesviruses (Epstein–Barr virus [EBV], human cytomegalovirus [HCMV], and human herpesvirus 6 [HHV6]) as causes of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). ME/CFS patients have elevated serum immunoglobulin (Ig)G serum antibody titers to EBV, HCMV, and HHV6, but there is no herpesvirus DNA-emia, herpesvirus antigenemia, or uniformly elevated IgM serum antibody titers to the complete virions. We propose that herpesvirus EBV, HCMV, and HHV6 immediate-early gene expression in ME/CFS patients leads to host cell dysregulation and host cell apoptosis without lytic herpesvirus replication. Specific antiviral nucleosides, which alleviate ME/CFS, namely valacyclovir for EBV ME/CFS and valganciclovir for HCMV/HHV6 ME/CFS, inhibit herpesvirus DNA polymerases and/or thymidine kinase functions, thus inhibiting lytic virus replication. New host cell recruitment thus ceases. In the absence of new herpesvirus, nonpermissive herpesvirus replication stops, and ME/CFS recovery ensues.

Keywords: ME/CFS, Epstein–Barr virus (EBV), human cytomegalovirus (HCMV), HHV6, abortive replication

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Readers of this article also read:

Patient-reported outcomes in type 2 diabetes mellitus: patients’ and primary care physicians’ perspectives in the Spanish health care system

Franch-Nadal J, Labrador Barba E, Gómez-García MC, Buil-Cosiales P, Millaruelo JM, Orera Peña ML

Patient Preference and Adherence 2015, 9:1413-1422

Published Date: 8 October 2015

Predictors of overall satisfaction of cancer patients undergoing radiation therapy

Becker-Schiebe M, Pinkert U, Ahmad T, Schäfer C, Hoffmann W, Franz H

Patient Preference and Adherence 2015, 9:1381-1388

Published Date: 29 September 2015

Mechanisms underlying probucol-induced hERG-channel deficiency

Shi YQ, Yan CC, Zhang X, Yan M, Liu LR, Geng HZ, Lv L, Li BX

Drug Design, Development and Therapy 2015, 9:3695-3704

Published Date: 20 July 2015

Parental bonding and attitudes toward suicide among medical college students in Japan

Hashimoto K, Sugawara N, Tanaka O, Nakamura K, Yasui-Furukori N

Neuropsychiatric Disease and Treatment 2014, 10:2015-2020

Published Date: 23 October 2014

Managing hemophilia: the role of mobile technology

Khair K, Holland M

Smart Homecare Technology and TeleHealth 2014, 2:39-44

Published Date: 6 May 2014

Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

Rao S, Song Y, Peddie F, Evans AM

International Journal of Nanomedicine 2011, 6:1245-1251

Published Date: 20 June 2011