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A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods

Authors Ankri R, Peretz V, Motiei M, Popovtzer R, Fixler D

Received 21 November 2011

Accepted for publication 9 December 2011

Published 31 January 2012 Volume 2012:7 Pages 449—455

DOI https://doi.org/10.2147/IJN.S28424

Review by Single-blind

Peer reviewer comments 3

Rinat Ankri, Vital Peretz, Menachem Motiei, Rachela Popovtzer, Dror Fixler
Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel

Abstract: This paper presents a new method for cancer detection based on diffusion reflection measurements. This method enables discrimination between cancerous and noncancerous tissues due to the intense light absorption of gold nanorods (GNRs), which are selectively targeted to squamous cell carcinoma head and neck cancer cells. Presented in this paper are tissue-like phantom and in vivo results that demonstrate the high sensitivity of diffusion reflection measurements to the absorption differences between the GNR-targeted cancerous tissue and normal, noncancerous tissue. This noninvasive and nonionizing optical detection method provides a highly sensitive, simple, and inexpensive tool for cancer detection.

Keywords: molecular imaging, nanoparticles, EGFR targeted, tissues’ optical properties

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