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A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation

Authors Hou AL, Xu WD

Received 19 May 2018

Accepted for publication 23 August 2018

Published 13 December 2018 Volume 2018:11 Pages 3171—3179

DOI https://doi.org/10.2147/JPR.S174663

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Michael A Überall


Ao-Lin Hou, Wen-Dong Xu

Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China

Background:
Neuropathic pain is a common and intractable sequel of brachial plexus injury.
Materials and methods: To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury.
Results: Behavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. GFAP expression in the cervical spinal cord appeared on day 1 post-injury and increased on day 4. Ionized calcium-binding adaptor molecule 1 expression appeared on day 1 post-injury and increased until day 28. Therefore, the brachial plexus avulsion injury model can imitate the development of neuropathic pain and maintain it.
Conclusion: The activation of astrocyte and microglia in the spinal cord plays a key role in the mechanism and treatment of neuropathic pain.

Keywords: neuropathic pain, new model, astrocyte, microglia

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