A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation
Authors Hou AL, Xu WD
Received 19 May 2018
Accepted for publication 23 August 2018
Published 13 December 2018 Volume 2018:11 Pages 3171—3179
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Michael A Überall
Ao-Lin Hou, Wen-Dong Xu
Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
Background: Neuropathic pain is a common and intractable sequel of brachial plexus injury.
Materials and methods: To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury.
Results: Behavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. GFAP expression in the cervical spinal cord appeared on day 1 post-injury and increased on day 4. Ionized calcium-binding adaptor molecule 1 expression appeared on day 1 post-injury and increased until day 28. Therefore, the brachial plexus avulsion injury model can imitate the development of neuropathic pain and maintain it.
Conclusion: The activation of astrocyte and microglia in the spinal cord plays a key role in the mechanism and treatment of neuropathic pain.
Keywords: neuropathic pain, new model, astrocyte, microglia
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]