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A large and aggressive fibromatosis in the axilla: a rare case report and review of the literature

Authors Duan M, Xing H, Wang K, Niu C, Jiang C, Zhang L, Ezzat S, Zhang L

Received 10 February 2018

Accepted for publication 25 April 2018

Published 28 May 2018 Volume 2018:11 Pages 3179—3184

DOI https://doi.org/10.2147/OTT.S165209

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 2

Editor who approved publication: Dr Samir Farghaly


Mingyue Duan,1 Hua Xing,1 Keren Wang,1 Chunbo Niu,2 Chengwei Jiang,2 Lijuan Zhang,1 Shereen Ezzat,3 Le Zhang1

1Department of Breast Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Pathology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 3Ontario Cancer Institute and The Endocrine Oncology Site Group, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada

Abstract: Aggressive fibromatosis (AF) is a rare benign tumor, which occurs in the deep part of bone and muscle fibrous tissue. Clinical and pathological features can be challenging for definitive diagnosis. Here, we report a rare case of a large AF in the axilla. Interestingly, 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography showed significant increase in standard uptake value. Surgical resection yielded a spindle cell tumor likely of fibromatosis origin which was positive for β-catenin expression.

Keywords: aggressive fibromatosis, desmoid-type fibromatosis, axilla, 18 F-fluorodeoxyglucose, PET/CT, β-catenin

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