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A current perspective on stereotactic body radiation therapy for pancreatic cancer

Authors Hong JC, Czito BG, Willett CG, Palta M

Received 21 May 2016

Accepted for publication 12 August 2016

Published 31 October 2016 Volume 2016:9 Pages 6733—6739

DOI https://doi.org/10.2147/OTT.S99826

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Professor Jianmin Xu


Julian C Hong, Brian G Czito, Christopher G Willett, Manisha Palta

Department of Radiation Oncology, Duke University, Durham, NC, USA

Abstract: Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or chemoradiation is associated with high rates of local tumor progression and metastases development, resulting in low survival rates. An emerging local modality is stereotactic body radiation therapy (SBRT), which uses image-guided, conformal, high-dose radiation. SBRT has demonstrated promising local control rates and resultant quality of life with acceptable rates of toxicity. Over the past decade, increasing clinical experience and data have supported SBRT as a local treatment modality. Nevertheless, additional research is required to further evaluate the role of SBRT and improve upon the persistently poor outcomes associated with pancreatic cancer. This review discusses the existing clinical experience and technical implementation of SBRT for pancreatic cancer and highlights the directions for ongoing and future studies.

Keywords: pancreatic cancer, stereotactic body radiation therapy, SBRT, radiation therapy

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