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A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention

Authors Wang J

Published 23 July 2009 Volume 2009:5 Pages 593—605

DOI https://doi.org/10.2147/VHRM.S6203

Review by Single-blind

Peer reviewer comments 3


Ji-Guang Wang

Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Abstract: Stroke is a leading cause of death and disability worldwide. The importance of lowering blood pressure for reducing the risk of stroke is well established. However, not all the benefits of antihypertensive treatments in stroke can be accounted for by reductions in BP and there may be differences between antihypertensive classes as to which provides optimal protection. Dihydropyridine calcium channel blockers, such as amlodipine, and angiotensin receptor blockers, such as valsartan, represent the two antihypertensive drug classes with the strongest supportive data for the prevention of stroke. Therefore, when combination therapy is required, a combination of these two antihypertensive classes represents a logical approach.

Keywords: stroke, angiotensin, calcium channel, cerebrovascular, hypertension, blood pressure

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