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A clinical perspective on the role of chronic inflammation in gastrointestinal cancer

Authors Rasch S, Algül H

Received 28 February 2014

Accepted for publication 30 May 2014

Published 11 August 2014 Volume 2014:7 Pages 261—272

DOI https://doi.org/10.2147/CEG.S43457

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Sebastian Rasch, Hana Algül

II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

Abstract: Chronic inflammation has been identified as an important risk factor for the development of malignancy, and knowledge about its molecular and cellular mechanisms is increasing. Several chronic inflammatory diseases of the gastrointestinal tract are important as risk factors for malignancy and have been studied in detail. In this review, we summarize important molecular mechanisms in chronic inflammation and highlight established and potential links between chronic inflammation and gastrointestinal cancer. In addition, we present the role of chronic inflammation in numerous tumors within the gastrointestinal tract as well as the relevant pathways or epidemiologic observations linking the pathogenesis of these tumors to inflammation.

Keywords: inflammation, immune response, carcinogenesis, gastrointestinal cancer, risk factor

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