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A case of small-cell lung cancer with adrenocorticotropic hormone deficiency induced by nivolumab

Authors Zhu Y, Wu HH, Wang W

Received 10 November 2018

Accepted for publication 21 January 2019

Published 25 March 2019 Volume 2019:12 Pages 2181—2186


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Arseniy Yuzhalin

Yan Zhu,1 Hong Hua Wu,2 Wei Wang2

1Department of Oncology, Peking University First Hospital, Beijing, China; 2Department of Endocrinology, Peking University First Hospital, Beijing, China

Abstract: Anti-programmed death-1 (anti-PD-1) monoclonal antibodies, such as nivolumab, have been used for the treatment of various types of cancers, and excellent efficacy has been shown in some patients. The adverse effects of anti-PD-1 antibodies relating to autoimmunity are different from traditional chemotherapeutic drugs and may involve many organs including the endocrine system. We herein describe a case of adrenocorticotropic hormone deficiency during the treatment of advanced small-cell lung cancer, probably caused by nivolumab-induced hypophysitis. The case showed nonspecific, insidious, as well as potentially life-threatening characters of immune-related adverse effects. It is important for physicians to acknowledge clinical features of the rare side effect and take appropriate and prompt treatment.

Keywords: PD-1 inhibitor, ACTH deficiency, immune checkpoint inhibitor, hypophysitis, immune-related adverse events

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