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A Case of Meningeal Carcinomatosis Due to Signet-Ring Cell Carcinoma That Developed Severe Visual Impairment with Papillary Swelling

Authors Sugaoka S, Kanda T, Ito M, Takeuchi M

Received 4 December 2019

Accepted for publication 27 February 2020

Published 14 May 2020 Volume 2020:13 Pages 153—158

DOI https://doi.org/10.2147/IMCRJ.S241026

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Shimpei Sugaoka,1 Takayuki Kanda,1 Masataka Ito,2 Masaru Takeuchi1

1Department of Ophthalmology, National Defense Medical College, Tokorozawa City, Saitama 359-8513, Japan; 2Department of Developmental Anatomy, National Defense Medical College, Tokorozawa City, Saitama 359-8513, Japan

Correspondence: Masaru Takeuchi
Department of Ophthalmology, National Defense Medical College, 3-2 Namiki, Tokorozawa City, Saitama 359-8513, Japan
Tel +81-4-2992-1511
Fax +81-4-2995-5332
Email masatake@ndmc.ac.jp

Purpose: To report a case of meningeal carcinomatosis by metastasis of signet-ring cell carcinoma resulting in severe visual impairment.
Case Presentation: A 49-year-old man visited our hospital complaining of blurred vision in his left eye since 2 months ago. There was no particular history. Best corrected visual acuity (BCVA) was 25/20 in the right eye and 20/20 in the left eye. Papillary swelling in both eyes and disc hemorrhage in the left eye were observed. Gradually, the frequency of dizziness increased, and magnetic resonance imaging (MRI) suggested ventricular enlargement, infiltration around the optic nerve, and meningeal carcinomatosis. Increased cerebrospinal fluid pressure was found, and metastatic adenocarcinoma cells were observed by cerebrospinal fluid cytology. A gastroduodenal biopsy confirmed the diagnosis of poorly differentiated adenocarcinoma with signet-ring cells. Visual acuity at the final visit was 4/200 in both eyes.
Conclusion: If papillary swelling is observed in both eyes, meningeal carcinomatosis should be considered as a differential diagnosis.

Keywords: meningeal carcinomatosis, signet-ring cell carcinoma, papillary swelling

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