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A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer

Authors Karakas Y, Esin E, Lacin S, Ceyhan K, Heper AO, Yalcin S

Received 24 August 2015

Accepted for publication 15 February 2016

Published 3 August 2016 Volume 2016:9 Pages 4815—4820

DOI https://doi.org/10.2147/OTT.S95020

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Dekuang Zhao

Peer reviewer comments 4

Editor who approved publication: Professor Daniele Santini


Yusuf Karakas,1 Ece Esin,1 Sahin Lacin,1 Koray Ceyhan,2 Aylin Okcu Heper,2 Suayib Yalcin1

1Medical Oncology Department, Hacettepe University Cancer Institute, 2Department of Medical Pathology, Ankara University School of Medicine, Ankara, Turkey

Abstract: A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigmentation on axillary, anal, and inguinal regions for the last 3 months, which were all progressive. The patient was referred to the oncology department with the diagnosis of acanthosis nigricans for investigation of an underlying malignancy. He was a smoker. A computed tomography scan of thorax revealed enlarged mediastinal lymphadenopathies and a lesion on the left upper lobe. Fine-needle aspiration biopsy of the mediastinal lesion was consistent with squamous cell carcinoma, and biopsies of the skin and oral mucosal lesion also further confirmed the diagnosis of acanthosis nigricans. After docetaxel and cisplatin chemotherapy, a significant improvement in his skin and mucosal lesions was observed with almost complete resolution of the pulmonary lesion and the mediastinal lymph nodes.

Keywords: acanthosis nigricans, squamous cell lung cancer, paraneoplastic syndrome

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