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A brief perspective on the diverging theories of lymphatic targeting with colloids

Authors Siram K, Marslin G, Vijaya Raghavan C, Balakumar K, Rahman H, Franklin G

Received 4 February 2016

Accepted for publication 14 April 2016

Published 15 June 2016 Volume 2016:11 Pages 2867—2872

DOI https://doi.org/10.2147/IJN.S105852

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Thomas Webster


Karthik Siram,1 Gregory Marslin,2 Chellan Vijaya Raghavan,1 Krishnamoorthy Balakumar,1 Habibur Rahman,1 Gregory Franklin3

1Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, India; 2Centre for the Research and Technology of Agro-Environment and Biological Sciences, University of Minho, Braga, Portugal; 3Department of Integrative Plant Biology, Institute of Plant Genetics, Polish Academy of Sciences, Poznan, Poland

Abstract: For targeted delivery of colloids to the lymphatic system, the colloids should efficiently reach and remain in the lymphatics for a considerable period of time. As per the current knowledge, diffusion and phagocytosis are the two mechanisms through which colloids reach the lymphatic system. Several parameters including particle size and charge have been shown to affect the direct uptake of colloids by the lymphatic system. Although many researchers attached ligands on the surface of colloids to promote phagocytosis-mediated lymphatic delivery, another school of thought suggests avoidance of phagocytosis by use of carriers like polyethylene glycol (PEG)ylated colloids to impart stealth attributes and evade phagocytosis. In this perspective, we weigh up the paradoxical theories and approaches available in the literature to draw conclusions on the conditions favorable for achieving efficient lymphatic targeting of colloids.

Keywords: lymphatic targeting, colloids, PEGylation, phagocytosis

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