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3D printing approaches for cardiac tissue engineering and role of immune modulation in tissue regeneration

Authors Qasim M, Haq F, Kang MH, Kim JH

Received 17 December 2018

Accepted for publication 26 January 2019

Published 20 February 2019 Volume 2019:14 Pages 1311—1333

DOI https://doi.org/10.2147/IJN.S189587

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 2

Editor who approved publication: Dr Thomas J Webster


Muhammad Qasim,1 Farhan Haq,2 Min-Hee Kang,1 Jin-Hoi Kim1

1Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Centre (SRC), Konkuk University, Seoul, South Korea; 2Department of Biosciences, Comsats University, Islamabad, Pakistan

Abstract: Conventional tissue engineering, cell therapy, and current medical approaches were shown to be successful in reducing mortality rate and complications caused by cardiovascular diseases (CVDs). But still they have many limitations to fully manage CVDs due to complex composition of native myocardium and microvascularization. Fabrication of fully functional construct to replace infarcted area or regeneration of progenitor cells is important to address CVDs burden. Three-dimensional (3D) printed scaffolds and 3D bioprinting technique have potential to develop fully functional heart construct that can integrate with native tissues rapidly. In this review, we presented an overview of 3D printed approaches for cardiac tissue engineering, and advances in 3D bioprinting of cardiac construct and models. We also discussed role of immune modulation to promote tissue regeneration.

Keywords: scaffolds, regeneration, cardiovascular diseases, cell therapy
 

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