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38-year-old woman with recurrent abdominal pain, but no fever

Authors Iwata K, Toma, Yachie A

Received 14 February 2012

Accepted for publication 22 February 2012

Published 22 March 2012 Volume 2012:5 Pages 265—268

DOI https://doi.org/10.2147/IJGM.S30867

Review by Single-blind

Peer reviewer comments 2

Kentaro Iwata1, Tomoko Toma2, Akihiro Yachie2

1Department of Infectious Diseases, Kobe University Hospital, Kobe, Japan; 2Department of Pediatrics, Graduate School of Medical Science and School of Medicine, Kanazawa University, Kanazawa, Japan

Abstract: A 38-year-old woman presented with 2 days history of left-flank pain. She had similar episodes of abdominal pain as well as chest pain several times, but symptoms disappeared spontaneously. Each time she developed pain, there was no fever. After ruling out common causes of recurrent abdominal pain, familial Mediterranean fever (FMF) was considered as a potential diagnosis. Genetic tests revealed multiple heterozygote mutations, which may be associated with FMF. Patients with Mediterranean fever mutations may present with atypical presentations without fever, like in this case. Astute clinical suspicion is required to make an accurate diagnosis.

Keywords: familial Mediterranean fever, MEFV mutation, afebrile

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