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Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors

Original Research

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Authors: M Gabrovska, F Geurs, S Ponette, et al

Published Date October 2009 Volume 2009:1 Pages 9 - 12
DOI: http://dx.doi.org/10.2147/HMER.S7574

M Gabrovska,1 F Geurs,1 S Ponette,2 J Ponette,2 K Bulte,2 L Derveaux,3 I Kempeneers4

1Depts of Medical Oncology, 2Gastroenterology, 3Pneumology and 4Surgery, Regionaal Ziekenhuis Sint Maria, Halle, Belgium

Abstract: Few data are available on patient management in jaundice caused by liver metastases of solid tumors (nonbreast and noncolon origin). We report the first patient series consecutively treated with cisplatin weekly in patients with severe jaundice and liver failure due to underlying metastatic neoplasms. In 4 out of 8 cases, liver function tests were reversed and jaundice disappeared, permitting subsequent standard chemotherapy. The other 4 patients died 3 to 5 weeks after admission, illustrating the extent and severity of the underlying neoplasm.

Keywords: liver failure, jaundice, metastases, chemotherapy, cisplatin






 

Other articles by Dr Filip Geurs

Complete response of a metastatic gastroesophageal adenocarcinoma on irinotecan-based chemotherapy in a dialysis patient
Urachal carcinoma with liver, lung, and brain metastases: benefit of a new combination chemotherapy (bevacizumab, 5-fluorouracil, irinotecan) – case report
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