Venous thromboembolism and pregnancy

Review

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Authors: Maristella D’Uva, Pierpaolo Di Micco, Ida Strina, et al

Published Date March 2010 Volume 2010:1 Pages 9 - 12

DOI: http://dx.doi.org/10.2147/JBM.S8747

Maristella D’Uva¹, Pierpaolo Di Micco², Ida Strina¹, Giuseppe De Placido

¹Department of Obstetrics and Gynecology and Human Reproduction, “Federico II” University of Naples, Naples, Italy; ²Internal Medicine Division, Buonconsiglio Fatebenefratelli Hospital of Naples, Naples, Italy

Abstract: In recent decades, the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL) has been studied extensively. Although the first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication such as venous thromboembolism (VTE) during pregnancy. Thromboprophylaxis should be considered also for pregnant subjects carriers of molecular thrombophilia or that previously experienced VTE, in order to prevent VTE during pregnancy, while antithrombotic treatment for VTE should be performed during all pregnant periods.

Keywords: thrombophilia, venous thromboembolism, recurrent pregnancy loss, factor V Leiden

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