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8852

Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review

Review

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Authors: Steve Fordan, Philip Raskin

Published Date February 2009 Volume 2009:5 Pages 225 - 231
DOI: http://dx.doi.org/10.2147/VHRM.S3402

Steve Fordan, Philip Raskin

Department of Medicine, Division, of Endocrinology, University of Texas, Southwestern Medical Center, Dallas, TX, USA

Abstract: The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.

Keywords: lispro, aspart, glulisine, nitric oxide synthetase, nuclear factor kappa B

 






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