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Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
Case report
(1854) Views (527) Full article downloads
Authors: Thorsten Gerstner, Nellie Bell, Stephan A Koenig
Published Date June 2008
Volume 2008:4(3) Pages 645 - 647
DOI: http://dx.doi.org/10.2147/TCRM.S2570
Thorsten Gerstner, Nellie Bell, Stephan A Koenig
University Children’s Hospital, Mannheim, Germany
Abstract: Valproic acid (VPA) is considered to be a drug of first choice for the therapy of generalized and focal epilepsies, including special epileptic syndromes. The drug is usually well tolerated, rare serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulapathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy. We report a case of VPA-associated encephalopathy without hyperammonemia in a 3-year-old girl with Pallister-Killian-Syndrom, combined with a mild hepatopathy and thrombopathy. After withdrawal of VPA, the clinical symptoms and the electroencephalography-alterations vanished rapidly.
Keywords: pallister-killian, valproate, encephalopathy, EEG, ammonia
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