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Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease

Review

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Authors: Giacomo Levantesi, Maria Giuseppina Silletta, Roberto Marchioli

Published Date July 2010 Volume 2010:3 Pages 79 - 96
DOI: http://dx.doi.org/10.2147/JMDH.S4743

Giacomo Levantesi, Maria Giuseppina Silletta, Roberto Marchioli

Laboratory of Clinical Epidemiology of Cardiovascular Disease, Consorzio Mario Negri Sud, Chieti, Italy

Abstract: Much evidence on the favorable effects of omega-3 ethyl esters on cardiovascular morbidity and mortality has been obtained in studies performed in healthy subjects and in different clinical settings. Here the clinical effects of omega-3 ethyl ester administration in patients with previous myocardial infarction or heart failure are reviewed, together with a discussion of underlying mechanisms of action. The pharmacokinetic and pharmacodynamic properties of omega-3 ethyl esters, as well as evidence concerning their safety and tolerability, are also reported.

Keywords: omega-3 ethyl esters, myocardial infarction, heart failure








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