International Journal of General Medicine
Open access peer-reviewed scientific and medical journals.
Dove Medical Press is now a member of the Open Access Initiative
An Author's Guide
A guide to help authors get their paper published.
Support Open Access and Dove Press
Promotional Article Monitoring - further details
Favored Author Program
Real benefits for authors, including fast-track processing of papers.
Usefulness of visual evaluation of the anterior thalamic radiation by diffusion tensor tractography for differentiating between Alzheimer’s disease and elderly major depressive disorder patients
(25085) Total Article Views
Authors: Niida A, Niida R, Kuniyoshi K, Motomura M, Uechi A
Published Date April 2013
Volume 2013:6 Pages 189 - 200
|Received:||18 January 2013|
|Accepted:||08 February 2013|
|Published:||04 April 2013|
Akira Niida,1 Richi Niida,2 Kazumasa Kuniyoshi,3 Makoto Motomura,4 Akihiko Uechi5
1Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, Japan; 2Department of Psychiatry, Nanto Clinic, Urasoe City, Okinawa, Japan; 3Department of Neuropathic Internal Medicine, Nanbu Hospital, Itoman City, Okinawa, Japan; 4Department of Human Sciences, University of the Ryukyus, Nakagami Country, Okinawa, Japan; 5Cognitive Neuroscience Research Project, Kansai Gaidai University, Hirakata City, Osaka, Japan
Background and objective: Many surveys of neural integrity of the cerebral white matter with psychiatric diseases on diffusion tensor imaging have recently been performed, but these mainly utilize fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) values, and the results were inconsistent and not fully applied clinically. In this study, we investigated the possibility of differentiating between Alzheimer’s disease (AD) and elderly major depressive disorder (MDD) patients in whom early-stage symptoms are difficult to diagnose, by visually evaluating cerebral nerve fascicles utilizing diffusion tensor tractography. We also measured and evaluated FA and ADC values at the same time.
Subjects and methods: The subjects included 13 AD patients (age: 69.5 ± 5.1 years), 19 MDD patients (65.8 ± 5.7 years), and 22 healthy control (HC) subjects (67.4 ± 4.8 years). Images were acquired using a 1.5T magnetic resonance imaging device and analyzed by diffusion tensor tractography analysis software.
Results: Depiction of the anterior thalamic radiation (ATR) tended to be poor in AD patients unlike in MDD patients and HC subjects. The FA values in the left superior longitudinal fasciculus and fornix (FX) in AD patients were significantly different from those in MDD patients and HC subjects. The ADC values in the bilateral ATR and left superior and inferior longitudinal fasciculi, left inferior fronto-occipital fasciculus, and FX in AD patients were significantly different from those in MDD patients and HC subjects.
Conclusion: Visual evaluation of the ATR in combination with the FA values of the left superior longitudinal fasciculus and FX and ADC values of the bilateral ATR, left superior and inferior longitudinal fasciculi, left inferior fronto-occipital fasciculus, and FX is useful for differentiating between AD and MDD patients, which further suggests that it may become a useful auxiliary diagnostic tool.
Keywords: Alzheimer’s disease, anterior thalamic radiation, diffusion tensor imaging, diffusion tensor tractography, MRI
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Other articles by Dr Akira Niida
Readers of this article also read:
"I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University.
- Diagnosis of depression by MRI scans with the use of VSRAD – a promising auxiliary means of diagnosis: a report of 10 years research
- Effects of selective serotonin reuptake inhibitors on motor neuron survival
- Review of evidence for immune evasion and persistent infection in Lyme disease
- Amino acid management of Parkinson’s disease: a case study