Back to Browse Journals » International Journal of Nanomedicine » Volume 4

Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain

Authors Soubir Basak, David Brogan, Hans Dietrich, Rogers Ritter, et al.

Published Date April 2009 Volume 2009:4 Pages 9—26

DOI http://dx.doi.org/10.2147/IJN.S4114

Published 1 April 2009

Soubir Basak1, David Brogan2, Hans Dietrich2, Rogers Ritter3, Ralph G Dacey2, Pratim Biswas1

1Aerosol and Air Quality Research Laboratory, Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, MO, USA; 2Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA; 3Stereotaxis Inc., St. Louis, MO, USA

Abstract: A current advance in nanotechnology is the selective targeting of therapeutics by external magnetic field-guided delivery. This is an important area of research in medicine. The use of magnetic forces results in the formation of agglomerated structures in the field region. The transport characteristics of these agglomerated structures are explored. A nonintrusive method based on in situ light-scattering techniques is used to characterize the velocity of such particles in a magnetic field gradient. A transport model for the chain-like agglomerates is developed based on these experimental observations. The transport characteristics of magnetic nanoparticle drug carriers are then explored in gel-based simulated models of the brain. Results of such measurements demonstrate decreased diffusion of magnetic nanoparticles when placed in a high magnetic field gradient.  

Keywords: nanoparticle ferrofluid, gel-brain model, drug delivery, magnetic agglomeration, transport, magnetic fields

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

The Copenhagen Primary Care Differential Count (CopDiff) database

Andersen CL, Siersma VD, Karlslund W, Hasselbalch HC, Felding P, Bjerrum OW, de Fine Olivarius N

Clinical Epidemiology 2014, 6:199-211

Published Date: 12 June 2014

Variability in contrast agent uptake by different but similar stem cell types

Ketkar-Atre A, Struys T, Soenen SJ, Lambrichts I, Verfaillie CM, De Cuyper M, Himmelreich U

International Journal of Nanomedicine 2013, 8:4577-4591

Published Date: 29 November 2013

The migration of synthetic magnetic nanoparticle labeled dendritic cells into lymph nodes with optical imaging

Su H, Mou YB, An YL, Han W, Huang XF, Xia GH, Ni YH, Zhang Y, Ma JM, Hu QG

International Journal of Nanomedicine 2013, 8:3737-3744

Published Date: 7 October 2013

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

Sun H, Chen X, Chen D, Dong M, Fu X, Li Q, Liu X, Wu Q, Qiu T, Wan T, Li S

International Journal of Nanomedicine 2012, 7:3295-3307

Published Date: 6 July 2012

The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals

Men Y, Wang XX, Li RJ, Zhang Y, Tian W, Yao HJ, Ju RJ, Ying X, Zhou J, Li N, Zhang L, Yu Y, Lu WL

International Journal of Nanomedicine 2011, 6:3125-3137

Published Date: 2 December 2011

RGD-tagged helical rosette nanotubes aggravate acute lipopolysaccharide-induced lung inflammation

Suri SS, Mills S, Aulakh GK, Rakotondradany F, Fenniri H, Singh B

International Journal of Nanomedicine 2011, 6:3113-3123

Published Date: 2 December 2011

Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes

Wang L, Zhang MY, Zhang N, Shi JJ, Zhang HL, Li M, Lu C, Zhang ZZ

International Journal of Nanomedicine 2011, 6:2641-2652

Published Date: 31 October 2011

Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

Jun Wang, Yue Chen, Baoan Chen, et al

International Journal of Nanomedicine 2010, 5:861-866

Published Date: 13 October 2010

Corneal abrasion

Scott Fraser

Clinical Ophthalmology 2010, 4:387-390

Published Date: 26 April 2010