Back to Browse Journals » Clinical Ophthalmology » Volume 4

Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children

Authors Kenji Yuda, Hiroshi Uozato, Naoto Hara, et al

Published Date April 2010 Volume 2010:4 Pages 251—260


Published 8 April 2010

Kenji Yuda1, Hiroshi Uozato2, Naoto Hara3, Wolfram Tetzlaff4, Satoru Hisahara5, Hiroko Horie6, Satomi Nakajima6, Hidenori Horie6,7

1Kikuna Yuda Eye Clinic, Yokohama, Japan; 2Department of Ophthalmology and Visual Science, Kitasato  University, Kanagawa, Japan; 3Department of Ophthalmology, Yokohama Dental and Medical Clinic, Kanagawa Dental College, Yokohama, Japan; 4ICORD, International Collaboration on Repair Discoveries, Univ. of British Columbia, Vancouver, BC, Canada; 5Panasonic Shikoku Electronics Co., Ltd., Yokohama, Japan; 6TechnoMaster Co., Ltd., Yokohama, Japan; 7Research Center of Brain and Oral Science, Kanagawa Dental College, Yokosuka, Japan

Purpose: Myopia in school-age children has become increasingly prevalent in industrialized countries, especially in Asia. A large population of school-age children still suffers from low visual acuity. We have developed a novel, safe and noninvasive training method to activate a pupillary constriction response during far accommodation that results in improved visual acuity.

Methods: Myopic children (n = 95) were treated for 3-minute sessions up to twice a week for 12–106 weeks. We stimulated quick cycles of near/far accommodation by displaying a visual object on a LCD screen and moving the screen in cycles from a near (25 cm) to a far (70 cm) point and back, while keeping the retinal projection size and brightness of the object constant.

Results: Mechanistically, we noted pupillary constriction upon far accommodation in trained myopic children, which was not seen in normal subjects or in untrained myopic children. Eighty five percent (52/61) of trained myopic right eyes with two sessions weekly experienced improved visual acuity (VA) by more than 0.1 logMAR units with an average improvement of 0.30 ± 0.03 standard error of mean (SEM) logMAR units. With maintained training, most eyes’ improved VA stayed almost constant, for more than 50 weeks in the case of 12 long trained subjects.

Conclusions: This simple, short and safe accommodation training greatly improves the quality of vision in a large population suffering from refractive abnormalities.
Keywords: accommodation, visual acuity, myopia, pupil constriction, training regimen

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Other article by this author:

Readers of this article also read:

Pharmacological enhancement of treatment for amblyopia

Rashad MA

Clinical Ophthalmology 2012, 6:409-416

Published Date: 15 March 2012

Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy

Gold M, Lorenzl S, Stewart AJ, Morimoto BH, Williams DR, Gozes I

Neuropsychiatric Disease and Treatment 2012, 8:85-93

Published Date: 9 February 2012

Fungus-mediated biological synthesis of gold nanoparticles: potential in detection of liver cancer

Chauhan A, Zubair S, Tufail S, Sherwani A, Sajid M, Raman SC, Azam A, Owais M

International Journal of Nanomedicine 2011, 6:2305-2319

Published Date: 12 October 2011

Central corneal thickness, intraocular pressure, and degree of myopia in an adult myopic population aged 20 to 40 years in southeast Spain: determination and relationships

Manuel Garcia-Medina, Jose Javier Garcia-Medina, Pablo Garrido-Fernandez, et al

Clinical Ophthalmology 2011, 5:249-258

Published Date: 28 February 2011

Palpation by blind examiners: A novel approach for glaucoma screening

Fatemeh Heidary, Reza Gharebaghi, Roghayeh Heidary

Clinical Ophthalmology 2010, 4:671-672

Published Date: 1 July 2010

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

Eduardo Pimenta, Suzanne Oparil

Vascular Health and Risk Management 2009, 5:453-463

Published Date: 19 May 2009