skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability

(2495) Views  (376) Full article downloads

Authors: Domenico D’Amico, Licia Grazzi, Gennaro Bussone

Published Date October 2006 Volume 2006:2(3) Pages 261 - 267
DOI: http://dx.doi.org/10.2147/NDT.S

Domenico D’Amico, Licia Grazzi, Gennaro Bussone

 

Headaches and Cerebrovascular Disorders Unit, C. Besta National Neurological Institute, Milan, Italy

 

Abstract: This paper reviews the results of placebo-controlled trials on topiramate (TPM) in the prophylaxis of migraine, focusing particularly on efficacy and tolerability of the target dose (100 mg/day). Data from well-conducted trials and analyses of pooled data show that TPM is effective against migraine, confirming the experience of physicians in various countries. High responder rate and good tolerability following slow titration suggest TPM as a first-line option for migraine prophylaxis. Patient acceptability may be enhanced by lack of weight gain, lack of major contraindications, and positive effects on quality of life.

 

Keywords: migraine, topiramate, prophylaxis, clinical trials, tolerability, acceptability








Readers of this article also read:

Prophylaxis of migraine
The use of combination therapies in the acute management of migraine
Beneficial effect of tibolone on mood, cognition, well-being, and sexuality in menopausal women
Longitudinal neurocognitive outcome in an adolescent with Hurler-Scheie syndrome
Treatment of phantom bite syndrome with milnacipran - a case series
A randomized controlled trial of quetiapine for psychosis in Parkinson’s disease
Fosphenytoin for the treatment of status epilepticus: an evidence-based assessment of its clinical and economic outcomes
Cost-effectiveness analysis of corticosteroid inhaler devices in primary care asthma management: A real world observational study
Reference values of hematological indices of infants, children, and adolescents in Port Harcourt, Nigeria
Nanostructured delivery system for zinc phthalocyanine: preparation, characterization, and phototoxicity study against human lung adenocarcinoma A549 cells