Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66

Qian Xu¹, Hongyan Lu¹, Jingchao Zhang¹, Guoyu Lu², Zhennan Deng², Anchun Mo³

¹State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, P.R. China; ²Research Center for Nano-Biomaterials, Sichuan University, Chengdu, 610064, P.R. China; ³Department of Oral Implant, West China College of Stomatology, Sichuan University, Chengdu, 610041, P.R. China

Abstract: The aim of the study was to investigate a porous nanohydroxyapatite/polyamide 66 (n-HA/PA66) scaffold material that was implanted into muscle and tibiae of 16 New Zealand white rabbits to evaluate the biocompatibility and osteogenesis and osteoinductivity of the materials in vivo. The samples were harvested at 2, 4, 12 and 26 weeks respectively, and subjected to histological analysis. At 2 weeks, the experiment showed that osteogenesis was detected in porous n-HA/PA66 composite and the density of new bone formation was similar to the surrounding host bone at 12 weeks. The study indicated that three-dimensional pore structures could facilitate cell adhesion, differentiation and proliferation, and help with fibrovascular and nerve colonization. In conclusion, porous n-HA/PA66 scaffold material could be a good candidate as a bone substitute material used in clinics due to its excellent histocompatibility, osteoconductivity and osteoinductivity.

Keywords: porous, nano hydroxyapatite, polyamide, interconnected porosity, biocompatibility, osteoconductivity, osteoinductivity