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Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent

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Authors: Gabriel Sosne, Ping Qiu, Michelle Kurpakus-Wheater

Published Date November 2007 Volume 2007:1(3) Pages 201 - 207
DOI: http://dx.doi.org/10.2147/OPTH.S

Gabriel Sosne1, Ping Qiu1, Michelle Kurpakus-Wheater2

1Department of Ophthalmology, Kresge Eye Institute, Detroit, MI, USA; 2Department of Biomedical Sciences, University of Detroit Mercy School of Dentistry, Detroit, MI, USA

Abstract: Thymosin beta 4 (Tβ4) is a low molecular weight protein present in all cells except erythrocytes. Although Tβ4 is the major monomeric actin-sequestering peptide in cells and can depolymerize F-actin, evidence is mounting to support the idea that it has multiple, seemingly diverse, cellular functions. In cornea, as in other tissues, Tβ4 promotes cell migration and wound healing, has anti-inflammatory properties, and suppresses apoptosis. In this review we discuss the current state of knowledge regarding the effects of Tβ4 in maintaining the healthy, functional cornea. The clinical implications of the use of Tβ4 as a wound healing and anti-inflammatory agent are discussed.

Keywords: apoptosis, cell migration, cornea, inflammation, thymosin beta 4, wound healing








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