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The pharmacology and therapeutic potential of (-)-huperzine A
Received 25 May 2012
Accepted for publication 14 July 2012
Published 6 September 2012 Volume 2012:4 Pages 113—123
DOI https://doi.org/10.2147/JEP.S27084
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Maung Kyaw Moe Tun, Seth B Herzon
Department of Chemistry, Yale University, New Haven, CT, USA
Abstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (–)-huperzine A (1). Synthetic studies of (–)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.
Keywords: Alzheimer's, NMDA, neurodegeneration, natural products, synthesis
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