The p53 breast cancer tissue biomarker in Indian women
This paper has been retracted.
Vinayak W Patil1, Mukund B Tayade2, Sangeeta A Pingale1, Shubhangi M Dalvi1, Rajesh B Rajekar1, Hemkant M Deshmukh1, Shital D Patil1, Rajeev Singhai1
1Department of Biochemistry, 2Department of General Surgery, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India
Background: Combination chemotherapy is highly effective in locally advanced breast cancer. A negative expression of biomarker p53 indicates a higher chance of responding to this regimen. Patients' p53 status may be used as a biological cancer marker to identify those who would benefit from more aggressive treatments.
Aims: The role of p53 in modulating apoptosis has suggested that it may affect the efficacy of anticancer agents. p53 alterations in 80 patients with locally advanced breast cancer IIIB undergoing neoadjuvant chemotherapy were prospectively evaluated.
Materials and methods: Patients received three cycles of paclitaxel (175 mg/m2) and doxorubicin (60 mg/m2) every 21 days. Tumor sections were analyzed before treatment for altered patterns of p53 expression, using immunohistochemistry and DNA sequencing.
Results: An overall response rate of 83.5% was obtained, including 15.1% complete pathological responses. The regimen was well tolerated with 17.7% grade 2/3 nausea and 12.8% grade 3/4 leukopenia. There was a statistically significant correlation between response and expression of p53. Of 25 patients who obtained a complete clinical response, only two were classified as p53-positive (P = 0.004, χ2). Of 11 patients who obtained a complete pathological remission, one was positive (P = 0.099, χ2).
Conclusion: Immunohistochemical (IHC) analysis has been shown to be a prognostic factor for patients with breast cancer in India. Paclitaxel is one of the most promising anticancer agents for the therapy of breast cancer, where it has also shown activity in tumors resistant to doxorubicin.
Keywords: breast cancer, doxorubicin, p53, paclitaxel, cancer tissue biomarkers, neoadjuvant chemotherapy, immunohistochemistry, infiltrating duct cancer
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Other articles by this author:
Patil AV, Bhamre RS, Singhai R, Tayade MB, Patil VW
Published Date: 19 April 2011
Singhai R, Patil VW, Patil AV
Published Date: 29 March 2011
Vinayak W Patil, Rajeev Singhai, Amit V Patil, et al
Published Date: 16 March 2011
Readers of this article also read:
Giusti A, Bianchi G
Published Date: 30 December 2014
Thomsen RW, Sørensen HT
Published Date: 18 December 2014
Çalık AN, Özcan KS, Yüksel G, Güngör B, Aruğarslan E, Varlibas F, Ekmekci A, Osmonov D, Tatlısu MA, Karaca M, Bolca O, Erdinler I
Published Date: 16 July 2014
Folate-targeted paclitaxel-conjugated polymeric micelles inhibits pulmonary metastatic hepatoma in experimental murine H22 metastasis models
Zhang Y, Zhang H, Wu WB, Zhang FH, Liu S, Wang R, Sun YC, Tong T, Jing XB
Published Date: 23 April 2014
Scleral buckling with a noncontact wide-angle viewing system in the management of retinal detachment with undetected retinal break: a case report
Kita M, Fujii Y, Kawagoe N, Hama S
Published Date: 21 March 2013
Development and characterization of a novel nanoemulsion drug-delivery system for potential application in oral delivery of protein drugs
Sun H, Liu K, Liu W, Wang W, Guo C, Tang B, Gu J, Zhang J, Li H, Mao X, Zou Q, Zeng H
Published Date: 26 October 2012
Brief G, Lammich T, Nagel E, Pfennigsdorf S, Spraul CW, Ho S
Published Date: 6 August 2012
De Caterina AR, Harper AR, Cuculi F
Published Date: 19 July 2012
Jalil MA, Moongfangklang N, Innate K, Mitatha S, Ali J, Yupapin PP
Published Date: 19 October 2011
Laparoscopic cholecystectomy under spinal anesthesia: comparative study between conventional-dose and low-dose hyperbaric bupivacaine
Imbelloni LE, Sant'Anna R, Fornasari M, Fialho JC
Published Date: 3 October 2011