Back to Browse Journals » Clinical Interventions in Aging » Volume 8

The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection

Authors Duplancic D, Cesarik M, Poljak NK, Radman M, Kovacic V, Radic J, Rogosic V

Published Date February 2013 Volume 2013:8 Pages 149—156


Received 20 September 2012, Accepted 2 November 2012, Published 11 February 2013

Darko Duplancic,1 Marijan Cesarik,2 Nikola Kolja Poljak,3 Maja Radman,4 Vedran Kovacic,5 Josipa Radic,5 Veljko Rogosic6

1Department of Cardiology, School of Medicine in Split, University Hospital Split, Split, Croatia; 2Department for Neurology, County General Hospital Pozega, Pozega, Croatia; 3Department of Otorhinolaryngology, 4Department of Endocrinology, 5Department of Nephrology, 6Department of Ophthalmology, School of Medicine in Split, University Hospital Split, Split, Croatia

Abstract: The ubiquitous distribution of vitamin D receptors in the human body is responsible for the pleiotropic effects of vitamin D-receptor activation. We discuss the possible beneficial effects of a selective activator of vitamin D receptor, paricalcitol, on the cardiovascular system in chronic heart failure patients and chronic kidney patients, in light of new trials. Paricalcitol should provide additional clinical benefits over the standard treatment for chronic kidney and heart failure, especially in cases of cardiorenal syndrome.

Keywords: vitamin D deficiency, cardiovascular system, albuminuria, inflammation

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Screening for subclinical atherosclerosis by noninvasive methods in asymptomatic patients with risk factors

Castellon X, Bogdanova V

Clinical Interventions in Aging 2013, 8:573-580

Published Date: 28 May 2013

Validation of a new mass screening tool for cognitive impairment: Cognitive Assessment for Dementia, iPad version

Onoda K, Hamano T, Nabika Y, Aoyama A, Takayoshi H, Nakagawa T, Ishihara M, Mitaki S, Yamaguchi T, Oguro H, Shiwaku K, Yamaguchi S

Clinical Interventions in Aging 2013, 8:353-360

Published Date: 26 March 2013

Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization

Piccirillo G, Moscucci F, Pascucci M, Pappadà MA, D’Alessandro G, Rossi P, Quaglione R, Di Barba D, Barillà F, Magrì D

Clinical Interventions in Aging 2013, 8:293-300

Published Date: 10 March 2013

Effects of balance training using a virtual-reality system in older fallers

Duque G, Boersma D, Loza-Diaz G, Hassan S, Suarez H, Geisinger D, Suriyaarachchi P, Sharma A, Demontiero O

Clinical Interventions in Aging 2013, 8:257-263

Published Date: 28 February 2013

A review of minodronic acid hydrate for the treatment of osteoporosis

Tanishima S, Morio Y

Clinical Interventions in Aging 2013, 8:185-189

Published Date: 15 February 2013

Taste loss in hospitalized multimorbid elderly subjects

Toffanello ED, Inelmen EM, Imoscopi A, Perissinotto E, Coin A, Miotto F, Donini LM, Cucinotta D, Barbagallo M, Manzato E, Sergi G

Clinical Interventions in Aging 2013, 8:167-174

Published Date: 13 February 2013

Anemia associated with chronic heart failure: current concepts

Shah R, Agarwal AK

Clinical Interventions in Aging 2013, 8:111-122

Published Date: 4 February 2013

Muscular effects of statins in the elderly female: a review

Bhardwaj S, Selvarajah S, Schneider EB

Clinical Interventions in Aging 2013, 8:47-59

Published Date: 18 January 2013