skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

The comparison of clinical outcomes of endophthalmitis from fluoroquinolone-resistant and susceptible bacteria

Original Research

(2131) Views  (578) Full article downloads

Authors: Anita R Shirodkar, Harry W Flynn Jr, Kyle Alliman, et al

Published Date April 2010 Volume 2010:4 Pages 211 - 214
DOI: http://dx.doi.org/10.2147/OPTH.S9839

Anita R Shirodkar, Harry W Flynn Jr, Kyle Alliman, Geeta A Lalwani, Chrisfouad Alabiad, Andrew A Moshfeghi, Darlene Miller

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA

Purpose: To identify patients who developed acute-onset endophthalmitis after clear corneal cataract surgery, and to compare treatment outcomes between cases caused by fluoroquinolone susceptible organisms versus fluoroquinolone resistant organisms.

Design: Retrospective case series.

Methods: Patients who developed endophthalmitis within six weeks of cataract surgery, and were treated between January 1996 and December 2008 at Bascom Palmer Eye Institute in Miami, Florida, were identified retrospectively. Clinical features, organisms cultured, and visual acuity outcomes were evaluated.

Results: A total of 97 patients met study criteria, and 37 (38%) demonstrated in vitro fluoroquinolone resistance. All fluoroquinolone resistant endophthalmitis in the study was caused by either Staphylococcus epidermidis (n = 32) or Staphylococcus aureus (n = 5). Presenting clinical features were similar between fluoroquinolone resistant and fluoroquinolone susceptible groups. Final visual acuity was ≥20/40 in 49% of fluoroquinolone-resistant cases and 42% of fluoroquinolonesusceptible cases. All fluoroquinolone-resistant isolates were susceptible to vancomycin.

Conclusion: In the current study, approximately one-third of isolates were resistant to fluoroquinolones. There was no significant difference in clinical outcomes in this study, regardless of fluoroquinolone susceptibility.

Keywords: endophthalmitis, fluoroquinolones








Readers of this article also read:

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Concentrations of besifloxacin, gatifloxacin, and moxifloxacin in human conjunctiva after topical ocular administration
Verteporfin photodynamic therapy combined with intravitreal triamcinolone for choroidal neovascularization due to angioid streaks
Correlation between morphology of optic disc determined by Heidelberg Retina Tomograph II and visual function in eyes with open-angle glaucoma
Methicillin resistance of Staphylococcus species among health care and nonhealth care workers undergoing cataract surgery
Pattern-reversal visual-evoked potential in patients with occult macular dystrophy
Steroid response pattern and outcome of pediatric idiopathic nephrotic syndrome: a single-center experience in northwest Iran
The relationship between deliberate self-harm behavior, body dissatisfaction, and suicide in adolescents: current concepts
Zinc oxide nanoparticles as selective killers of proliferating cells
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy