Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy

Xiang-Hong Peng^1,4, Ximei Qian^2,4, Hui Mao^3,4, Andrew Y Wang⁵, Zhuo (Georgia) Chen^1,4, Shuming Nie^2,4, Dong M Shin^1,4*

¹Department of Medical Oncology/Hematology; ²Department of Biomedical Engineering; ³Department of Radiology; ⁴Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; ⁵Ocean Nanotech, LLC, Fayetteville, AR, USA

Abstract: Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups for cross-linking to tumor-targeting ligands such as monoclonal antibodies, peptides, or small molecules for diagnostic imaging or delivery of therapeutic agents. IO nanoparticles possess unique paramagnetic properties, which generate significant susceptibility effects resulting in strong T₂ and T*₂ contrast, as well as T₁ effects at very low concentrations for magnetic resonance imaging (MRI), which is widely used for clinical oncology imaging. We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy.

Keywords: iron oxide nanoparticles, tumor imaging, MRI, therapy