Back to Journals » Pragmatic and Observational Research » Volume 2

Original Research

Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)

       

Authors Dekoninck J, Geurs F, De Loecker R, Deprest Y

Published 28 July 2011 Volume 2011:2 Pages 13—18

DOI https://doi.org/10.2147/POR.S15391

Review by Single anonymous peer review

Peer reviewer comments 2

Download Article [PDF] 


J Dekoninck1, F Geurs1, R De Loecker2, Y Deprest2
1Department of Medical Oncology, 2Laboratory, Regional Hospital Sint Maria, Halle, Belgium

Abstract: In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.

Keywords: bone resorption, bisphosphonates, CTX levels, VAS score

 

Creative Commons License © 2011 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]