Back to Browse Journals » Journal of Inflammation Research » Volume 4

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

Authors Devesa I, Planells-Cases R, Fernández-Ballester GJ, González-Ros JM, Ferrer-Montiel AV, Fernández-Carvajal AM

Published Date May 2011 Volume 2011:4 Pages 67—81


Published 24 May 2011

Isabel Devesa1, Rosa Planells-Cases2, Gregorio Fernández-Ballester1, José Manuel González-Ros1, Antonio Ferrer-Montiel1, Asia Fernández-Carvajal1
1Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante; 2Centro de Investigación Príncipe Felipe, Valencia, Spain

Abstract: The transient receptor potential vanilloid 1 (TRPV1) is a thermoreceptor that responds to noxious temperatures, as well as to chemical agonists, such as vanilloids and protons. In addition, its channel activity is notably potentiated by proinflammatory mediators released upon tissue damage. The TRPV1 contribution to sensory neuron sensitization by proalgesic agents has signaled this receptor as a prime target for analgesic and anti-inflammatory drug intervention. However, TRPV1 antagonists have notably failed in clinical and preclinical studies because of their unwanted side effects. Recent reports have unveiled previously unrecognized anti-inflammatory and protective functions of TRPV1 in several diseases. For instance, this channel has been suggested to play an anti-inflammatory role in sepsis. Therefore, the use of potent TRPV1 antagonists as a general strategy to treat inflammation must be cautiously considered, given the deleterious effects that may arise from inhibiting the population of channels that have a protective function. The use of TRPV1 antagonists may be limited to treating those pathologies where enhanced receptor activity contributes to the inflamed state. Alternatively, therapeutic paradigms, such as reduction of inflammatory-mediated increase of receptor expression in the cell surface, may be a better strategy to prevent abrogation of the TRPV1 subpopulation involved in anti-inflammatory and protective processes.

Keywords: transient receptor potential, nociceptor, capsaicin, pain, ion channel, analgesia

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Immune response profiles after caterpillar exposure: a case report

Tamar A Smith-Norowitz, Kevin B Norowitz, Stephan Kohlhoff, et al

Journal of Inflammation Research 2010, 3:45-51

Published Date: 16 July 2010

Prostate cancer cells undergoing ER stress in vitro and in vivo activate transcription of pro-inflammatory cytokines

Navin R Mahadevan, Antonio Fernandez, Jeffrey J Rodvold, et al

Journal of Inflammation Research 2010, 3:99-103

Published Date: 20 August 2010

The effect of smoking on the symptoms and progression of multiple sclerosis: a review

Afsaneh Shirani, Helen Tremlett

Journal of Inflammation Research 2010, 3:115-126

Published Date: 1 September 2010

Attenuation of niacin-induced prostaglandin D2 generation by omega-3 fatty acids in THP-1 macrophages and Langerhans dendritic cells

VanHorn J, Altenburg JD, Harvey KA, Xu Z, Kovacs RJ, Siddiqui RA

Journal of Inflammation Research 2012, 5:37-50

Published Date: 14 March 2012

Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock

Charchaflieh J, Labaze GI, Li P, Van Remmen H, Lee H, Stutz H, Richardson A, Emanuel A, Zhang M

Journal of Inflammation Research 2012, 5:51-58

Published Date: 24 July 2012

Morphine treatment alters nucleotidase activities in rat blood serum

Rozisky JR, Nonose Y, Laste G, dos Santos VS, de Macedo IC, Battastini AM, Caumo W, Torres IL

Journal of Experimental Pharmacology 2012, 4:187-193

Published Date: 17 December 2012

Case of invasive nontypable Haemophilus influenzae respiratory tract infection with a large quantity of neutrophil extracellular traps in sputum

Hamaguchi S, Seki M, Yamamoto N, Hirose T, Matsumoto N, Irisawa T, Takegawa R, Shimazu T, Tomono K

Journal of Inflammation Research 2012, 5:137-140

Published Date: 18 December 2012

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis

Bergin DA, Hurley K, Mehta A, Cox S, Ryan D, O’Neill SJ, Reeves EP, McElvaney NG

Journal of Inflammation Research 2013, 6:1-11

Published Date: 23 January 2013

Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6

Kersting S, Reinecke K, Hilgert C, Janot MS, Haarmann E, Albrecht M, Müller AM, Herdegen T, Mittelkötter U, Uhl W, Chromik AM

Journal of Inflammation Research 2013, 6:13-23

Published Date: 12 February 2013