skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8852

Role of TGF-β on cardiac structural and electrical remodeling

Review

(2382) Views  (661) Full article downloads

Authors: Roberto Ramos-Mondragón, Carlos A Galindo, Guillermo Avila

Published Date October 2008 Volume 2008:4(6) Pages 1289 - 1300
DOI: http://dx.doi.org/10.2147/VHRM.S3985

Roberto Ramos-Mondragón, Carlos A Galindo, Guillermo Avila

Departamento de Bioquímica, Cinvestav-IPN, México

Abstract: The type β transforming growth factors (TGF-βs) are involved in a number of human diseases, including heart failure and myocardial arrhythmias. In fact, during the last 20 years numerous studies have demonstrated that TGF-β affects the architecture of the heart under both normal and pathological conditions. Moreover, TGF-β signaling is currently under investigation, with the aim of discovering potential therapeutic roles in human disease. In contrast, only few studies have investigated whether TGF-β affects electrophysiological properties of the heart. This fact is surprising since electrical remodeling represents an important substrate for cardiac disease. This review discusses the potential role of TGF-β on cardiac excitation-contraction (EC) coupling, action potentials, and ion channels. We also discuss the effects of TGF-β on cardiac development and disease from structural and electrophysiological points of view.

Keywords: transforming growth factor, ion channel, cardiac electrophysiology






 

Other articles by Dr Guillermo Avila



Readers of this article also read:
  • Join ISVH

    Be part of the World's leading experts in vascular health by joining the International Society of Vascular Health (ISVH)

  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University