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Role of telavancin in treatment of skin and skin structure infections

Review

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Authors: Joseph Bonkowski, Anne R Daniels, William J Peppard

Published Date October 2010 Volume 2010:3 Pages 127 - 133
DOI: http://dx.doi.org/10.2147/CCID.S9027

Joseph Bonkowski1, Anne R Daniels2, William J Peppard2
1University of Wisconsin-Madison, Madison, WI, USA; 2Froedtert Hospital, Milwaukee, WI, USA

Abstract: Skin and skin structure infections (SSSIs) are a common diagnosis encountered by ambulatory and inpatient practitioners across the country. As the SSSIs become more complicated, they require increased health care resources and often involve hospitalization and intravenous antimicrobials. Complicated SSSIs are caused by a variety of pathogens, including Gram-positive, Gram-negative, and anerobic bacteria. Empiric broad-spectrum antibiotic coverage is warranted, taking into account area disease-state epidemiology and antimicrobial susceptibility data. Telavancin is an antimicrobial agent with a broad Gram-positive spectrum of activity which was recently approved for the treatment of SSSIs. It may especially benefit patients with resistant organisms, such as methicillin-resistant Staphylococcus aureus. This article reviews telavancin and its pharmacology, efficacy, and safety data to enhance the practitioner’s knowledge base on the appropriateness of telavancin for the treatment of SSSIs.

Keywords: skin and skin structure infections, telavancin, methicillin-resistant Staphylococcus aureus




 

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