Role of endocannabinoids in regulating drug dependence

Review

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Authors: Daniela Parolaro, Daniela Vigano’, Natalia Realini, Tiziana Rubino

Published Date January 2007 Volume 2007:3(6) Pages 711 - 721

DOI: http://dx.doi.org/10.2147/NDT.S976

Daniela Parolaro, Daniela Vigano’, Natalia Realini, Tiziana Rubino

Neuroscience Center, DBSF, University of Insubria, Busto Arsizio, Italy

Abstract: This review will discuss the latest knowledge of how the endocannabinoid system might be involved in treating addiction to the most common illicit drugs. Experimental models are providing increasing evidence for the pharmacological management of endocannabinoid signaling not only to block the direct reinforcing effects of cannabis, opioids, nicotine and ethanol, but also for preventing relapse to the various drugs of abuse, including opioids, cocaine, nicotine, alcohol and metamphetamine. Preclinical and clinical studies suggest that the endocannabinoid system can be manipulated by the CB1 receptor antagonist SR141716A, that might constitute a new generation of compounds for treating addiction across different classes of abused drugs.

Keywords: Endocannabinoids, drug dependence, opioids, nicotine, alcohol, psychostimulants