Role of atazanavir in the treatment of HIV infection

Review

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Authors: Pablo Rivas, Judit Morello, Carolina Garrido, Sonia Rodríguez-Nóvoa, Vincent Soriano

Published Date December 2008 Volume 2009:5 Pages 99 - 116

DOI: http://dx.doi.org/10.2147/TCRM.S3114

Pablo Rivas¹, Judit Morello², Carolina Garrido¹, Sonia Rodríguez-Nóvoa², Vincent Soriano¹

¹Department of Infectious Diseases; ²Pharmacology Unit, Hospital Carlos III, Madrid, Spain

Abstract: Atazanavir (ATV) is one of the latest protease inhibitors (PI) approved for the treatment of HIV infection. The drug has a relatively long-life (∼7 h) and large inhibitory quotient which allows once daily administration. It is generally well tolerated and the main side effect is hyperbilirubinemia, since ATV inhibits the hepatic uridin-glucoronyl-transferase. A signature mutation at the protease gene, I50L, may confer loss of susceptibility to the drug. Interestingly, it produces hypersusceptibility to all other PIs. When ATV is pharmacokinetically boosted with ritonavir (r) 100 mg/day, a greater genetic barrier for resistance is achieved, and generally more than 3 major PI resistance associated mutations are needed to result in ATV resistance. In drug-naïve subjects, regimens based on ATV/r have shown non-inferiority compared to lopinavir (LPV)/r (CASTLE study) or fosamprenavir/r (ALERT trial), generally with improved tolerance (less diarrhea and dyslipidemia). Given its good tolerance and convenience, ATV has been proven to be successful as a simplification strategy in switch studies (ie, SWAN and SLOAT) conducted in patients with complete virological suppression under other PI-based regimens. Finally, ATV/r-based combinations have shown to be equivalent in terms of viral response to other PI/r-containing regimens, including LPV/r, in rescue interventions in patients failing other PI regimens (ie, studies AI424-045 and NADIS).

Keywords: atazanavir, HIV, protease inhibitors, drug resistance

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