Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections

Review

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Author: Darlene Miller

Published Date March 2008 Volume 2008:2(1) Pages 77 - 91

DOI: http://dx.doi.org/10.2147/OPTH.S1666

Darlene Miller

Abrams Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, Anne Bates Leach Eye Hospital, Miller School of Medicine-University of Miami, FL, USA

Abstract: Moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox^®) is the ocular formulation/adaptation of moxifloxacin. Moxifloxacin is a broad spectrum 8-methoxyfluoroquinolone which terminates bacterial growth by binding to DNA gyrase (topoisomerase II) and topoisomerase IV, essential bacterial enzymes involved in the replication, translation, repair and recombination of deoxyribonucleic acid. Affinity for both enzymes improves potency and reduces the probability of selecting resistant bacterial subpopulations. Vigamox is a bactericidal, concentration dependent, anti-infective. It is preservative free, and well tolerated with minimal ocular side effects. It provides increased penetration into ocular tissues and fluids with improved activity against Streptococci and Staphylococci species and moderate to excellent activity against clinically relevant, gram- negative ocular pathogens.

Keywords: moxifloxacin, vigamox, pharmacodynamic indices, minimal inhibitory concentrations