Retrospective chart review of a referenced EEG database in assisting medication selection for treatment of depression in patients with eating disorders

James M Greenblatt¹, Craig Sussman¹, Mariko Jameson¹, Lee Yuan¹, Daniel A Hoffman², Dan V Iosifescu^3
1Comprehensive Psychiatric Resources, Waltham, MA, USA; ²Neuro-Therapy Clinic Inc, Denver, CO, USA; ³Mood and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY, USA

Background: A retrospective chart review was undertaken in a private clinic to examine the clinical outcomes for patients with an eating disorder comorbid with depression or bipolar illness who underwent a referenced electroencephalographic (EEG) database analysis to help guide medication selection.
Method: We examined 33 charts for patients with the primary psychiatric diagnosis of an eating disorder and comorbid major depressive disorder or bipolar disorder who underwent a quantitative EEG database assessment to provide additional information for choices of medication. The current analysis includes data from 22 subjects who accepted treatments based on information from the referenced-EEG medication database. Hamilton Depression Rating Scale, Clinical Global Impression-Severity, Clinical Global Impression-Improvement, and hospitalization data were examined for these patients.
Results: Patients whose EEG data was used for clinical treatment reported significant decreases in associated depressive symptoms (HDRS scores), overall severity of illness (Clinical Global Impression-Severity), and overall clinical global improvement (Clinical Global Impression-Improvement). This cohort also reported fewer inpatient, residential, and partial hospitalization program days following referenced-EEG compared with the two-year period prior to treatment.
Conclusion: These findings are consistent with previously reported data for patients with eating disorders and suggest the need for future studies using EEG data correlated with those from other patients with similar quantitative EEG features.

Keywords: eating disorders, anorexia, bulimia, depression, referenced-EEG, chart review