Repeated renal infarction in native and transplanted kidneys due to left ventricular thrombus formation caused by antiphospholipid antibody syndrome

Paul Scully,¹ Daniel C Leckstroem,¹ Andrew McGrath,² John Chambers,³ David J Goldsmith<sup>1

1</sup>Nephrology Department, ²Radiology Department, ³Cardiology Department, King's Health Partners, Academic Health Sciences Centre, London, United Kingdom

Abstract: Antiphospholipid syndrome can be a feature of several underlying conditions, such as lupus, but it can also occur idiopathically. Diagnosis usually comes after investigation of recurrent venous or arterial thromboses, emboli, or hypertension/proteinuria where the kidney is involved and is usually confirmed by laboratory testing. We describe a case of a man with a myocardial infarction who developed mural thrombus in an akinetic left ventricular segment but then who recurrently embolized first to one of his native kidneys and then later to a transplanted kidney. Although the clinical behavior was typical of antiphospholipid syndrome, it took numerous laboratory assays over many years until finally the problem was confirmed and life-long warfarin therapy instituted.

Keywords: antiphospholipid therapy, emboli, infarction, kidney, kidney transplant