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8852

Recent advances in the treatment of multiple sclerosis

Review

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Authors: Jeffrey L Bennett, Augusto A Miravalle

Published Date November 2010 Volume 2010:2 Pages 155 - 161
DOI: http://dx.doi.org/10.2147/JEP.S7822

Jeffrey L Bennett, Augusto A Miravalle
University of Colorado, Aurora, CO, USA

Abstract: Multiple sclerosis (MS) is a chronic inflammatory, immune-mediated, demyelinating, neurodegenerative disorder of the central nervous system. Despite the lack of an etiologic factor, it has been consistently demonstrated that the immune system plays a crucial role in the pathogenesis of MS. The traditional description of immunopathogenesis of MS suggests a preferential CD4+ TH1 cell activity causing tissue damage by the release of pro-inflammatory cytokines and subsequent demyelination and axonal loss. Recent evidence, however, suggests that other immune cells including TH17 cells, CD8+ effector T cells, CD4+ CD25+ regulatory T cells, and B cells may play a prominent role in MS immunopathology. A better understanding of the molecular and cellular components of the immunopathogenesis of MS is allowing the development of novel therapies.

Keywords: multiple sclerosis, immunopathology, oral medication, clinical trial






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