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8852

Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection

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Authors: Lisa M Chirch, Roy T Steigbigel

Published Date April 2010 Volume 2010:3 Pages 15 - 23
DOI: http://dx.doi.org/10.2147/IDR.S9689

Lisa M Chirch, Roy T Steigbigel

Division of Infectious Diseases, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York, USA

Abstract: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unusual given its recent availability, but resistance with identified viral mutation pathways in the integrase gene in patients receiving the drug does occur.

Keywords: raltegravir, integrase, human immunodeficiency virus, drug resistance








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