Profile of Xeomin^® (incobotulinumtoxinA) for the treatment of blepharospasm

Juwan Park¹, Michael S Lee², Andrew R Harrison^3
1Department of Ophthalmology, The Catholic University of Korea, Seoul, Korea; ²Department of Ophthalmology, Neurology and Neurosurgery, ³Department of Ophthalmology and Otolaryngology, University of Minnesota, MN, USA

Abstract: Even though conventional botulinum neurotoxin (BoNT) products have shown successful treatment results in patients with benign blepharospasm (BEB), the main, potential long-term side effect of BoNT use is the development of immunologic resistance due to the production of neutralizing antibody to the neurotoxin after repeated injections. Xeomin^® (incobotulinumtoxinA), a unique botulinum neurotoxin type A (BoNT/A) drug free of complexing proteins otherwise contained in all conventional BoNT/A drugs, was recently approved by US Food and Drug Administration for the treatment of cervical dystonia or blepharospasm in adults. The newly approved BoNT/A drug may overcome this limitation of previous conventional products, since it contains pure neurotoxin (150 kDa) through a manufacturing process that separates it from complexing proteins such as hemagglutinins produced by fermentation of Clostridium botulinum. Many studies have also shown that Xeomin^® has the same efficacy and safety profile as complexing protein-containing products such as Botox^® and is exchangeable with Botox^® using a simple 1:1 conversion ratio. Xeomin^® represents a new treatment option for the repeated treatment of patients with blepharospasm in that it may reduce antibody-induced therapy failure. But, long-term comparative trials in naïve patients between Xeomin^® and conventional BoNT/A drugs are required to confirm the low immunogenicity of Xeomin^®.

Keywords: blepharospasm, botulinum neurotoxin type A, Xeomin^®, incobotulinumtoxinA, complexing proteins, neutralizing antibodies